LYMPHOID NEOPLASIA Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
نویسندگان
چکیده
1Division of Molecular Oncology, San Raffaele Scientific Institute, Milano, Italy; 2Università degli Studi di Milano-Bicocca, Milano, Italy; 3Pathology Unit, San Raffaele Scientific Institute, Milano, Italy; 4Vita-Salute San Raffaele University, Milano, Italy; 5Laboratory of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Rozzano, Milano, Italy; 6Clinical Unit of Lymphoid Malignancies, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy
منابع مشابه
Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models.
Inflammation is involved in the initiation and progression of several chronic lymphoid malignancies of B-cell type. Toll-like receptors (TLR) are transmembrane inflammatory receptors that on recognition of pathogen-associated molecular patterns trigger an innate immune response and bridge the innate and adaptive immune response by acting as costimulatory signals for B cells. Fine tuning of TLR ...
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